Browsing by Author "Özpolat, Bülent"
Now showing items 1-2 of 2
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Dual Suppressive Effect of miR-34a on the FOXM1/eEF2-Kinase Axis Regulates Triple-Negative Breast Cancer Growth and Invasion
Bayraktar, Recep; Ivan, Cristina; Bayraktar, Emine; Kanlikilicer, Pınar; Kabil, Nashwa N.; Kahraman, Nermin; Özpolat, Bülent; Arslan, Ahmet (Amer Assoc Cancer Research, 2018)Purpose: Recent studies indicated that dysregulation of noncoding KNAs (ncRNA) such as miRNAs is involved in pathogenesis of various human cancers. However, the molecular mechanisms underlying miR-34a are not fully understood ... -
Target-Driven Design of a Coumarinyl Chalcone Scaffold Based Novel EF2 Kinase Inhibitor Suppresses Breast Cancer Growth in Vivo
Cömert Önder, F.; Kahraman, N.; Bellur Atıcı, E.; Cagır, A.; Kandemir, Hakan; Tatar, G.; Özpolat, Bülent (American Chemical Society, 2021)Eukaryotic elongation factor 2 kinase (eEF-2K) is an unusual alpha kinase involved in protein synthesis through phosphorylation of elongation factor 2 (EF2). eEF-2K is highly overexpressed in breast cancer, and its activity ...